PlGF

Makes blood vessels grow

Placental growth factor (PlGF) is a naturally occurring protein which acts to promote the formation of blood vessels. PlGF is produced by recombinant DNA technology. The use of PlGF was exclusively in-licensed by ThromboGenics from the VIB . The Company has also concluded a partnership with Geymonat, which owns exclusive rights to the composition-of-matter patent for PlGF.

The main categories of disease that could benefit from treatment with PlGF are peripheral vascular occlusive disease (PAOD) and coronary artery disease (CAD). In patients with severe PAOD or CAD, who are not amenable to surgery, the prevention of further tissue death, or potentially even the recovery of damaged tissue, may be achieved with PlGF. PlGF may promote angiogenesis (new blood vessel formation) and offer considerable hope to patients who are not eligible for coronary intervention. Pre-clinical pharmacology experiments indicate that PlGF could potentially induce a significant number of new and fully functional blood vessels.